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Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03621891
Enrollment
80
Registered
2018-08-09
Start date
2016-05-01
Completion date
2017-05-01
Last updated
2018-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis, Occlusal Trauma

Keywords

hyper-occlusion, hypoxia, occlusal trauma, periodontitis, subgingival microbiota

Brief summary

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

Detailed description

Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.

Interventions

None listed

Sponsors

Tokat Gaziosmanpasa University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
29 Years to 42 Years
Healthy volunteers
Yes

Inclusion criteria

* Systemical health * No drug use * No pregnancy or lactation For group 3 and 4; * Bruxism at least for 2 years * Occlusal trauma * Existence of at least 20 functioning teeth

Exclusion criteria

* Smoking * Pregnancy/lactation * Systemical disease * Drug use * Absence of at least 20 functioning teeth

Design outcomes

Primary

MeasureTime frameDescription
Determination of certain bacterial species in subgingival dental plaqueA day after initial examinationSubgingival dental plaque samples were collected from each participant and evaluated via polymerase-chain reaction.

Secondary

MeasureTime frameDescription
hypoxic changes in gingiva and serumOne day after initial examinationDetermination of the hypoxia inducible factor-alpha and vascular endothelial growth factor via ELISA

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026