Ovarian Reserve
Conditions
Brief summary
Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed. Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve. The analysis has been made to compare the efficacy of both procedures.
Detailed description
The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.
Interventions
PROCEDUREblood rich plasma platelets
Injection of blood rich platelet into the ovaries.
DIETARY_SUPPLEMENTAntioxidant therapy
Antioxidants: Q10, DHEA, Vitamina E, Vitamin C, Omega 3
Sponsors
Lucy Coleman
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Prospective comparative study
Eligibility
Sex/Gender
FEMALE
Age
38 Years to 46 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 38 and 46 years * FSH\> 12 mIU * Estradiol \> 100 pg/ml * AMH \< 0.8 ng/mL
Exclusion criteria
* Pelvic inflammatory syndrome * vaginal pathologies * known history of hyperandrogenism * diagnosed platelet disorders as adhesion * aggregation * disorder of thromboxane synthesis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| variation of hormones FSH and LH directly involved with ovarian reserve | 18 months | Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with FSH-LH post-treatment. |
| variation of AMH directly involved with ovarian reserve in both groups | 18 months | Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with AMH values. |
| variation in recruitment of antral follicles in both groups | 18 months | Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with the number of astral follicles available. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of good quality eggs obtained in both groups after IVF | 18 months | Egg quality is evaluated in both group of women undergoing IVF after bio-stimulation or antioxidant therapy are performed |
| Number and quality of fertilised eggs obtained in both groups after IVF | 18 months | the number and quality of fertilised eggs is evaluated in both groups of women undergoing IVF after bio-stimulation or antioxidant therapy is performed. |
Countries
Venezuela
Outcome results
None listed