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Effect of Tai Chi Exercise on Mechanical Joint Loading in Knee Osteoarthritis

Real Time Biofeedback Tai Chi Training for Knee Osteoarthritis: A Feasibility Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03621631
Enrollment
15
Registered
2018-08-08
Start date
2018-08-27
Completion date
2024-07-31
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

knee osteoarthritis, Tai Chi, Biofeedback, External Knee Adduction Moment

Brief summary

This project is designed to identify the biomechanical mechanisms of Tai Chi (TC) exercise and test a novel optimized TC intervention by modifying newly identified mechanisms for those with knee osteoarthritis (OA) and to assess the changes in mechanical load with the intervention. It combines unique real time torque biofeedback approach, and uses external knee adduction moment (EKAM) as modulation target tailored to TC intervention in this population. The potential benefit from this project is to provide biomechanical insights of TC and this novel TC approach may produce meaningful changes of mechanical load in these patients who can learn and practice safely during this intervention.

Detailed description

Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional TC intervention has been a promising therapeutic intervention in knee OA, but the efficacy of TC as a knee OA intervention has proven inconclusive presumably because individuals with knee OA perform different TC components (steps) with widely varying mechanical knee joint loads. This variation could be a confounding factor in the way in which TC affects knee OA. Therefore, a feasibility study is proposed here to quantify external knee adduction moment (EKAM) response to the different TC steps, and then determine if it is feasible to use biofeedback of torque acting on the knee to modify some TC steps so as to reduce the EKAM they produce. Those TC steps whose EKAM can be easily reduced below mean EKAM during walking and those already below that level will constitute an optimized form of TC for knee OA; the remainder will be discarded. A phase 1 randomized controlled trial will be conducted to compare the optimized TC intervention to traditional TC training in reducing EKAM. The proposed research represents the first study to identify the biomechanical mechanisms of TC and to target EKAM by using a real-time biofeedback approach to manipulate EKAM during TC performance.

Interventions

BEHAVIORALOptimized Tai Chi intervention

Optimized Tai Chi intervention

BEHAVIORALTraditional Tai Chi intervention

Traditional Tai Chi intervention

Sponsors

National Center for Complementary and Integrative Health (NCCIH)
CollaboratorNIH
The University of Texas Health Science Center at San Antonio
CollaboratorOTHER
Edward Via Virginia College of Osteopathic Medicine
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* OA participants will be diagnosed based on the American College of Rheumatology classification criteria. * Knee pain average level \> 3 cm on a 10 cm visual analog scale, * Kellgren / Lawrence scale of 2-3 on radiographs. * Pain/tenderness over the medial region or lateral region of the knee on physical examination. * The participants will have 40 years of age or older and have no TCC experience prior this study.

Exclusion criteria

* a history of lower extremity joint replacement * intra-articular knee injection (steroid, hyaluronic acid) within the previous 6 months * systemic rheumatoid arthritic condition affecting the knee clinically or radiographically, * report of any of the following health problems (heart condition, chest pain during periods of activity or rest) * currently seeking or receiving physical therapy for knee OA, * having a medical condition precluding the participant from undergoing physical activity or biomechanical gait analysis.

Design outcomes

Primary

MeasureTime frameDescription
change from baseline knee joint mechanical load at 4 weeksbaseline and 4 weeksknee joint mechanical load will be measured by using high speed cameras and force plates to estimate external knee adduction moment (EKAM)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026