Colorectal Polyps
Conditions
Brief summary
Probe-based confocal laser endomicroscopy (pCLE) has been shown to a reliable diagnostic method enabling in vivo microscopic imaging during ongoing endoscopy. Usually fluorescein then serves as a contrast agent for pCLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects. This study aimed to establish a single topical dye, cresyl violet (CV) for pCLE imaging, to describe pCLE interpretation criteria for the characterization of colorectal polyps with histopathological correlation, and to perform the validation of these criteria.
Interventions
None listed
Sponsors
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged from 18 to 75 years, with polyps found during surveillance or screening colonoscopies.
Exclusion criteria
* Contraindications to CV (such as allergy); * Pregnancy or breastfeeding; * Serous cardiopulmonary diseases, severe coagulopathy dysfunction, impaired kidney function; * Inability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The pCLE with topical CV interpretation criteria for the characterization of colorectal polyps with histopathological correlation | 5 months |
| Number of diagnostic agreement between pCLE with topical CV and histopathological results | 5 months |
| Number of participants with procedure-related adverse events | 5 months |
| Number of pCLE imaging failure with topical CV | 5 months |
Countries
China
Contacts
Primary ContactYanqing Li, PhD. MD.
Outcome results
None listed