Zinc Supplement Before or With Food in Generally Healthy Men

Evaluation of Zinc Supplementation Taken Prior or With Food

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03619421

Enrollment

Registered

2018-08-07

Start date

2018-08-21

Completion date

2019-04-15

Last updated

2019-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Zinc Deficiency, Dyslipidemias, Zinc Excess, Inflammation

Keywords

zinc, nutrition, supplement, food

Brief summary

The purpose of this study is to determine the influence of food consumption timing on the body's response to a zinc supplement

Detailed description

This research is a dietary intervention study designed to evaluate the effect of the food consumption timing on the absorption of zinc supplement. The main objective is to measure plasma zinc in generally healthy male subjects, who will consume zinc supplement with food or 30-min before food for 2-weeks. In addition to the primary objectives, correlations in enzyme activity with changes in fat metabolism, namely circulating triglyceride and cholesterol, will be determined. This will enable the determination of the effect of a low Zn intake on various aspects of dyslipidemia.

Interventions

DIETARY_SUPPLEMENTZinc supplement

25 mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Masking description

Random number used to label samples

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* willing to stop supplementation 4 weeks prior to start of the study * has an operative understanding of English * no plans to move from the area during the study period * regularly eat breakfast

Exclusion criteria

* Chronic or acute metabolic disease * smoker or user of nicotine products * history of alcohol abuse, or use of illicit drugs (incl marijuana) * Is underweight or overweight, body mass index (BMI) \< 18 or \> 30 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Plasma Zinc changes	Day 0, Day 15	Change in plasma zinc

Secondary

Measure	Time frame	Description
Body weight changes	Day 0, Day 15	Body weight changes
Essential Fatty acid changes	Day 0, Day 15	Essential Fatty acid changes
Blood glucose changes	Day 0, Day 15	Blood glucose changes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026