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The Incidence of Respiratory Symptoms Associated With the Use of HFNO

The Incidence and Severity of Upper Respiratory Tract Symptoms Associated With The Use of High-Flow Humidified Nasal Oxygen (HFNO)

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03619148
Enrollment
30
Registered
2018-08-07
Start date
2018-09-05
Completion date
2019-04-26
Last updated
2022-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Brief summary

Optiflow (high flow humified nasal oxygen) is used in several settings frequently (ICU, during elective general anaesthesia- commonly here on the TOE list, in certain ENT patients, and more commonly now in obese or obstetric patients for preoxygenation). To the investigators knowledge no one has quantified the common complications associated with it (based on a literature search in November 2017 using PubMed and Google; using the search terms high flow nasal oxygen combined with complications, side effects, nasal dryness and epistaxis). The investigators were unable to find any existing research that examined the days following HFNO use and specifically looked for minor side effects) The investigators have had anecdotal feedback from patients that they tend to experience respiratory symptoms post HFNO. THe investigators would like to determine how often this occurs and how long it lasts for which would be pertinent to consent, and informing patients prior to the procedure, and also serve to improve the literature on this up and coming technique.

Detailed description

The study aims to evaluate what is the frequency and severity of respiratory tract symptoms following the use of high flow nasal humidified oxygen? Participants will be from 2 sub groups: 1. Patients already undergoing TOE (as this is the most common and consistent group who have optiflow- about 4-5 patients per week) 2. Volunteers (staff) who would agree to experience the optiflow whilst awake for the same period as those undergoing TOE The study will involve a 7 day follow up survey to see if they had experienced complications (runny nose, nasal discomfort, sore throat, epistaxis), what their severity was and how long they lasted for.

Interventions

DEVICEHigh-Flow Humidified Nasal Oxygen

High-Flow Humidified Nasal Oxygen

Sponsors

Torbay and South Devon NHS Foundation Trust
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

2 sub group will be recruited: 1. patient undergoing TOE 2. Staff volunteers

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Volunteers (staff) - from the anaesthetics department and willing to be exposed to HFNO 2. Patients listed for all those undergoing elective TOE requiring sedation and use of HFNO 3. present at Torbay Hospital 4. Greater than 18 years of age. No upper age limit 5. Able to give informed consent

Exclusion criteria

1. patient refusal 2. lack of capacity 3. poor understanding of English 4. respiratory tract symptoms 5. blocked nostrils 6. current or recurrent epistaxis 7. nasal steroid treatment 8. Ages \<18 years 9. Unable to give informed consent

Design outcomes

Primary

MeasureTime frameDescription
Incidence of respiratory tract symptoms7 daystelephone survey after 7 days

Secondary

MeasureTime frameDescription
severity of respiratory tract symptoms7 daystelephone survey after 7 days

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026