Reduction of Post Intravitreal Injection Bleeding and Pain by Ice

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03618875

Enrollment

Registered

2018-08-07

Start date

2017-01-01

Completion date

2017-11-25

Last updated

2018-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

Intravitreal injections are an efficient method for delivering intraocular therapeutic agents in numerous ophthalmologic diseases. However, side effects, such as pain and subconjunctival hemorrhage remain a major concern. Prevention or alleviation of those side effects might shorten the healing duration and improve patients' quality of life.

Detailed description

cooling the eye using ice patched prior to Intravitreal injections may ameliorated pain and subconjunctival hemorrhage incidences.

Interventions

OTHERice pack

ice pack was placed on eyelid 5 minutes prior to IVIT

OTHERroom temperature pack

room temperature pack was placed on eyelid 5 minutes prior to IVIT

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

patients receiving intravitreal injection

Design outcomes

Primary

Measure	Time frame	Description
pain	change between VAS pain score at baseline and 10 minutes	Visual Analogue Scale (VAS) is a Likert-type scale (1-10). The VAS is a reliable tool in evaluating and quantifying ocular discomfort

Secondary

Measure	Time frame	Description
size of subconjunctival hemorrhage	change between subconjunctival hemorrhage at baseline and 10 minutes	subconjunctival hemorrhage in mm

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026