Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale

Preterm Birth

Bacterial vaginosis, Vaginal microbiota, Molecular methods, Next generation sequencing

Objective To compare vaginal microbiota in the first trimester of pregnancy between spontaneous preterm and term deliveries

Material and methods Case-control study nested in a cohort of pregnant patients in the first trimester. Inclusion criteria. : case is defined as spontaneous preterm births between 22 and 36 weeks in one of the 14 centers. The control patient will be considered as the following delivery over ≥ 37 weeks in the same center. Multiple pregnancies, medical interruptions of pregnancy and deaths in utero will be excluded. Regarding the vaginal flora of cases and controls, the microorganisms will be researched and quantified by molecular methods. Expected results Patients and control patients will be compared for their demographic, obstetric, clinical and microbiological data. The parameters related to the risk of spontaneous prematurity at the p \<0.20 threshold will then be analyzed by multi-level logistic regression. Implications At a time when the link between bacterial vaginosis and prematurity is controversial, the detection - or not - of microorganisms linked to the risk of prematurity will be a key issue.

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