Obstructive Sleep Apnea of Adult
Conditions
Keywords
obstructive sleep apnea, intermittent hypoxia, granulocyte function, continuous positive airway pressure (CPAP) therapy
Brief summary
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy. Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.
Detailed description
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included. Healthy controls without OSA are enrolled, too. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy (not given to controls). Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.
Interventions
None listed
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\<OSA group\> 1. Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis 2. aged 20 years or older 3. Apnea-hypopnea index (AHI) at least 15/hour 4. Willing to participate this study \<Control group\> 1. Healthy controls without OSA 2. aged 20 years or older 3. AHI less than 5/hour
Exclusion criteria
\<OSA group\> 1. OSA patients who do not need continuous positive airway pressure (CPAP) therapy 2. OSA Patients have ever received CPAP or other treatment 3. aged less than 20 years 4. AHI at least 15/hour 5. Not willing to participate this study \<Control group\> 1\. Apnea-hypopnea index (AHI) equals to or more than 5/hour 2. aged less than 20 years 3. Not willing to participate this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Granuolocyte function | On enrollment | Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability. |
Countries
Taiwan
Contacts
Primary ContactKun-Ta Chou, M.D
Outcome results
None listed