Myeloma
Conditions
Brief summary
The investigators wish to determine which anatomic regions need to be explored in order to correctly diagnose myeloma: whether axial skeletal MRI alone is sufficient or whether it is necessary to perform a total skeletal MRI.
Interventions
DIAGNOSTIC_TESTMRI
Skeletal MRI and pelvic and spinal MRI
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is at least 18 years old * Patient has been diagnosed with multiple myeloma (\> 10% medullary plasma cells + monoclonal protein) or symptomatic myeloma (myeloma + CRAB symptoms (hypercalcemia, renal failure, anemia, bone lesions), or indolent myeloma (myeloma with symptomatic criteria).
Exclusion criteria
* The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * The patient is pregnant or breast feeding * The patient has an absolute contra-indication for MRI (pace-maker, claustrophobic patient, metal heart valve)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of focal lesions ≥ 5mm by axial skeletal MRI of spine and pelvis versus whole-body MRI using diffusion sequences | Day 0 | Fatty tissue replacement by tumoral tissue observed by hyposignal T1 and hypersignal T2 FS or short-TI Inversion Recovery ≥ 5mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Agreement between identification of normal lesions ≥ 5mm by axial skeletal MRI of spine and pelvis versus whole-body MRI using diffusion sequences | Day 0 | — |
| Agreement between identification of diffuse lesions ≥ 5mm by axial skeletal MRI of spine and pelvis versus whole-body MRI using diffusion sequences | Day 0 | — |
| Agreement between identification of mixed lesions ≥ 5mm by axial skeletal MRI of spine and pelvis versus whole-body MRI using diffusion sequences | Day 0 | — |
| Number of punched out lesions ≥ 5mm identified by whole-body MRI with diffusion sequences versus skeletal X-ray | Day 0 | — |
| Link between type of infiltration and spinal cord karyotype | Day 0 | Yes/no presence of anomaly, and if yes, type of karyotype anomaly |
| Inter-observer reproducibility for the first 20 patients for the detection of focal lesions ≥ 5mm by axial skeletal MRI of spine and pelvis | Day 0 | — |
| Agreement between identification of salt and pepper lesions ≥ 5mm by axial skeletal MRI of spine and pelvis versus whole-body MRI using diffusion sequences | Day 0 | — |
Countries
France
Outcome results
None listed