Cognitive Impairment
Conditions
Keywords
African Americans, neurological exam, Dementia, Alzheimer's Disease
Brief summary
The researchers are trying to gather information and learn more about imaging tests in racially different people who are cognitively normal or have dementia.
Interventions
COMBINATION_PRODUCTTau PET scan
Patient will receive a dose of flutaucipir and be scanned appropriately
Sponsors
Mayo Clinic
National Institute on Aging (NIA)
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or female African Americans 30 years of age or older * Subjects who have completed or are scheduled to undergo the neurological evaluation procedures described below.
Exclusion criteria
* Subjects unable to lie down without moving for 20 minutes. * Women who are pregnant or cannot stop breast feeding for 24 hours. * Claustrophobic patients unable to tolerate the scans. * Subjects with a prolonged QT interval (as demonstrated by ECG test) cannot participate in the Tau-PET scans. * Standard safety exclusionary criteria for MRI such as metallic foreign bodies, pacemaker, etc, since the quantitative PET data analysis is based on anatomic criteria that are established uniquely for each subject by registration to his/her MRI.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tau positive scans | 5 years | Percentage of each of the three groups with tau positive scans |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORNeill R Graff-Radford, MD
Mayo Clinic
Outcome results
None listed