Healthy Adults
Conditions
Brief summary
The effects of modafinil on measures of brain electrical activity will be tested.
Interventions
DRUGModafinil
Drug: modafinil Each participant receives a single pill of placebo or active drug (modafinil 100 mg or 200 mg) 30 minutes after arriving at the lab. The participant then completes approximately 6 hours of testing in the laboratory. The participant stays at the lab for 7.5 hours in order to monitor physical condition in case the participant received the active pill. One week later, that participant receives a single pill of an alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and two active pills, each time separated by one week. Other Names: Provigil Alertec Modavigil
DRUGplacebo
Drug: Placebo Each participant receives a single pill of placebo or active drug (modafinil 100 mg or 200 mg) 30 minutes after arriving at the lab. The participant then completes approximately 6 hours of testing in the laboratory. The participant stays at the lab for 7.5 hours in order to monitor physical condition in case the participant received the active pill. One week later, that participant receives a single pill of an alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and two active pills, each time separated by one week.
Sponsors
University of California, San Diego
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
University of California, San Diego Experimental Pharmacy randomizes dose order and provides masked pills
Intervention model description
Experimental medicine model; not an intervention. Within-subject double-blind placebo-controlled dose-response study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Exclusion criteria
* history of substance abuse * mental illness in a first degree relative * significant medical illness (e.g. cancer, diabetes, heart disease, HIV) * history of seizure * open head injury or closed head injury with loss of consciousness \> 1 min * pregnancy * current psychotropic drug use * R-hand injury * hearing or visual impairment * urine toxicology positive for recreational drug use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reward Positivity | 1 year | Frontal alpha power by block in the probabilistic learning task |
| Motivation Signal | 1 year | Parietal EEG alpha power peak in first - final step toward breakpoint |
Countries
United States
Outcome results
None listed