The Mechanism and Prognosis of Pulmonary Circulation Dysfunction

The Mechanism and Prognosis of Pulmonary Circulation Dysfunction in Pulmonary Injury and Recovery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03616366

Enrollment

1000

Registered

2018-08-06

Start date

2018-08-10

Completion date

2020-12-31

Last updated

2018-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

VTE

Keywords

VTE, SNP, biomarkers

Brief summary

Venous thromboembolism (VTE) is a condition which influenced by both environmental and genetic factors. This study is going to explore new significant Single nucleotide polymorphisms (SNPs) associated with VTE by Genome-Wide Association Studies (GWAS) and bioinformatics analysis. Transcriptomics and cytokine antibody array are also used to find new biomarkers of VTE's early diagnosis, severity and prognosis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Chinese Han population older than 14 years old * Acute VTE patients diagnosed in 1 month * With informed consent

Exclusion criteria

* Patients with psychosis * Patients with contraindications for computed tomographic pulmonary angiography (CTPA) * Chronic VTE * Recurrence of chronic VTE

Design outcomes

Primary

Measure	Time frame	Description
All cause death	6 months	death

Secondary

Measure	Time frame	Description
Venous thromboembolism (VTE) recurrence	6months	VTE recurrence detected by echocardiography or CTPA scan
chronic thromboembolism pulmonary hypertension(CTEPH)	6 months	newly developed CTEPH detected by pulmonary angiography

Countries

China

Contacts

Primary ContactJianguo He, MD

hejianguofw@163.com80-10-88398060

Outcome results