Hookah Smoking
Conditions
Brief summary
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.
Detailed description
The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.
Interventions
OTHERHookah smoking
ad lib hookah smoking for 30 minutes in a controlled laboratory environment.
Sponsors
University of California, Los Angeles
University of California, San Francisco
Cedars-Sinai Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 29 years of age * Habitual Hookah smoker defined as having smoked Hookah \>=12 times in the past 12 months * Have not smoked cigarettes within the past 12 months
Exclusion criteria
* History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease * Exhaled carbon monoxide level \>10 ppm * BP \< 140/90 mmHg * BMI \<18.5 or \> 30 kg•m2 * Resting heart rate \> 100 beats/min * Taking prescription medication * History of illicit drug use * Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial artery flow-mediated dilation | change from baseline to immediately after smoking |
Secondary
| Measure | Time frame |
|---|---|
| Reactive hyperemia peripheral arterial tonometry | change from baseline to immediately after smoking |
Other
| Measure | Time frame |
|---|---|
| Pulse wave velocity | change from baseline to immediately after smoking |
| aortic pressure waveform | change from baseline to immediately after smoking |
Countries
United States
Outcome results
None listed