Healthy, Females, Bone, Inflammation
Conditions
Keywords
Bone Health, Females, Dairy, Exercise, Inflammation
Brief summary
This study analyzes whether dairy supplementation positively impacts loading exercise-induced bone cell activity and inflammation in healthy young females.
Detailed description
Introduction: Two million individuals at a cost of around 2.3 billion dollars a year in Canada suffer from osteoporosis. Research that emphasizes the treatment of this disease is important, but so is research that focuses on prevention; reducing bone loss and/or increasing bone mass when young. In addition, inflammation is an issue as it strongly relates to chronic disease. Countermeasures to improve bone health and inflammation, such as nutrition and exercise, should be explored and implemented. The proposed research combines both nutrition and exercise along with the assessment of bone turnover markers and inflammation in healthy young females, and aims to determine whether dairy versus a carbohydrate-based beverage positively impacts acute bone turnover and the inflammatory response following a bout of resistance and plyometric exercise. Design: Randomized controlled crossover trial. Participants: 13 healthy university aged females. Methods: Participants were asked to complete 2 different acute exercise and nutritional supplement trials. Each trial will be assigned in random order. The two trials were: 1) exercise+carbohydrate (CHO), and 2) exercise+milk (Milk). The whole study, per participant, took a maximum of 8-12 weeks to complete as each supplement trial was separated by \ 4 weeks. Each treatment is outlined below. \*\*\*\*\*\*DUE TO COVID-19, we removed the treatment trial which involved milk+creatine supplementation. Despite randomization, and before the trial was closed, only 11 participants completed this trial\*\*\*\*\*\*\*\* Anticipated Results: The investigators anticipate that dairy and exercise will have a greater positive impact on acute bone cell activity and inflammation in healthy young females compared to exercise and CHO.
Interventions
BEHAVIORALResistance and Plyometric Exercise
A single resistance and plyometric exercise bout per trial.
DIETARY_SUPPLEMENTCarbohydrate (Maltodextrin powder mixed with water)
50 grams immediately after exercise bout. 50 grams 1 hour after exercise bout.
DIETARY_SUPPLEMENTSkim Milk
500 ml immediately after exercise bout. 500 ml 1 hour after exercise bout.
Sponsors
Brock University
York University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Masking description
Those completing the analyses were masked to the treatments.
Intervention model description
Randomized acute Crossover Trial
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Female between the ages of 18 and 30 years * Normal BMI (18.5-24.9) kg/m2 * Low to moderately physically active (0-2 times/week) * No allergy to dairy protein or lactose intolerance * On no medication related to a chronic condition * On birth control (or not but with regular mensural cycle)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute Bone Cell Activity | Baseline | Bone markers (OPG, RANKL, OC) measured in serum/plasma. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Inflammation | Baseline | Interleukin 6, Interleukin 10, Interleukin 1B, TNFa measured in serum/plasma. |
Countries
Canada
Outcome results
None listed