Hypertension
Conditions
Keywords
Exercise, Aging, Ambulatory Blood Pressure Monitoring, Power Exercise
Brief summary
The main purpose of the present study was to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension. As secondary outcomes, the investigators compared post-exercise hypotension, BP variability, and endothelial function between older men and women with hypertension. The working hypothesis was that a single bout of power exercise would decrease both office and 24 h BP in comparison to a non-exercising control session and men and women would respond differently after a power training session.
Detailed description
Participants randomly performed two experimental sessions: power exercise training (PT) and non-exercising control at seated rest (Con). They maintained their current antihypertensive medications throughout the trial. Each session was composed of 20 min of rest in the supine position, 40 min of PT or Con protocols, and 60 min of rest in supine position after protocols. The PT was composed of 3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed as fast as possible while the eccentric phase lasted 1-2 seconds. During the Con, the participants remained seated rest on the same exercise machines, but without any exercise. Standardized office BP was performed before and during the first hour (in intervals of 15 min) after exercise and control sessions. Together with the office BP evaluation in the pre and post sessions, the endothelium-dependent brachial vascular function was evaluated using Flow-mediated dilation. Afterwards, participants underwent 24h ambulatory BP monitoring..
Interventions
BEHAVIORALPower Training Session
3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed as fast as possible while the eccentric phase lasted 1-2 seconds.
Sponsors
Federal University of Rio Grande do Sul
Hospital de Clinicas de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
The randomization list was generated by an epidemiologist using a computer software. This epidemiologist did not participate in the recruitment or assignment to the experimental sessions. Participants and the research team were blinded to the randomization list until the moment of assignment.
Intervention model description
A randomized controlled clinical trial with crossover design was performed in order to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension.
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Office blood pressure between 130-179 and 80-110 mmHg for systolic and diastolic blood pressure, respectively; * Non-engaged in structured programs of exercise for the last 3 months since the beginning of this study; * Able to perform the proposed exercises.
Exclusion criteria
* Underlying cardiovascular disease previously diagnosticated by a doctor, occurred in the last 24 months, such as: acute myocardial infarction, angina, stroke or heart failure; * Diseases that reduce life expectancy; * Smokers and ex-smokers for less than six months; * BMI \> 39.9 kg/m² * diabetic proliferative retinopathy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ambulatory Blood Pressure Monitoring | 24 hours after control and power training exercise session | Mean 24-h, day-time, night-time of blood pressure in mmHg will be assessed after each experimental session (power training session and control session) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Office Systolic Blood Pressure | 60 minutes after control and power training exercise session | Systolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour |
| Office Diastolic Blood Pressure | 60 minutes after control and power training exercise session | Diastolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour |
| Endothelial Function | 60 minutes after control and power training exercise session | Flow-mediated dilatation (FMD) assessed through high resolution ultrasonography before and after each experimental session throughout one hour |
| Blood Pressure Variability | 24 hours after control and power training exercise session | Systolic and diastolic BP values obtained in the 24-hour ambulatory blood pressure monitoring, with valid measures included in a programmed software to calculate the average real variability of these measures. |
Other
| Measure | Time frame |
|---|---|
| Sex Differences in Ambulatory Blood Pressure Monitoring, Office Blood Pressure, Endothelial Function and Blood Pressure Variability | 60 minutes and 24 hours after control and power training exercise session |
Countries
Brazil
Outcome results
None listed