Horner Syndrome
Conditions
Keywords
Alpha blockers, Tamsulosin
Brief summary
This study is evaluating the pupil dilation of Horner's Patients who have ever taken an alpha blocker such as Tamsulosin. Patients will undergo eye dilation as would occur at a yearly eye examination, but their pupil dilation measurements will be recorded.
Detailed description
This study will enroll 10 participants who have a unilateral Horner's Syndrome AND have a history of taking an alpha blocker such as Tamsulosin. Participants will be recruited based on those two enrollment criteria, and after consenting they will undergo pupil dilation with 10% phenylephrine. Once fully dilated the pupil size will be measured. Pupil dilation size of the eye affected by the Horner's Syndrome will be compared to the eye not affected by Horner's. Primary study outcome is the comparative dilation size of the Horner's affected eye to the non affected eye in all subjects.
Interventions
DRUG10% phenylephrine
10% phenylephrine is a drug that can be used to dilate patient's eyes at their yearly eye examination. All enrolled subjects will receive this drug for their eye dilation.
Sponsors
University of Colorado, Denver
Denver Health and Hospital Authority
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Single arm, intervention trial.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Horner's Syndrome 2. History of taking an alpha blocker (tamsulosin/ terazosin/doxazosin/alfuzosin/silodosin) medication
Exclusion criteria
1. Subjects with untreated hypertension 2. Subjects with thyrotoxicosis 3. Pregnant women 4. Prisoners 5. Inability to consent 6. Subjects with anatomical narrow angles who have never had a dilated exam
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pupil Size Measurements | 20-30 minutes after 10% phenylephrine has been placed in each eye. | pupil dilation measurements will be taken of each eye at the eye examination. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| 10% Phenylephrine All patients will receive 10% phenylephrine at their eye examination as the drug to dilate the pupil. After pupil dilation, pupil size will be measured.
10% phenylephrine: 10% phenylephrine is a drug that can be used to dilate patient's eyes at their yearly eye examination. All enrolled subjects will receive this drug for their eye dilation. | 0 |
| Total | 0 |
Baseline characteristics
| Characteristic | — |
|---|---|
| Region of Enrollment United States | — participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 0 |
| other Total, other adverse events | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 |
Outcome results
Primary
Pupil Size Measurements
pupil dilation measurements will be taken of each eye at the eye examination.
Time frame: 20-30 minutes after 10% phenylephrine has been placed in each eye.
Population: Study incomplete. Only 1 subject enrolled and data not reported for 1 participant for privacy reasons.