Breast Cancer, Chronic Pain, Serratus Plane Block
Conditions
Brief summary
A prospective, double-blinded randomized controlled, 1-year follow-up study was designed to compare the analgesic effect of serratus plane block (SPB) after breast cancer surgery. Women undergoing radical mastectomy were dIvided into Control group and SPB group. The postoperative acute pain was evaluated by numerical rating scale (NRS) and the effect of preventing chronic pain was assessed at 3, 6, 12 months after surgery by NRS.
Interventions
PROCEDUREserratus plane block with local anesthetic
The high-frequency linear array ultrasound transducer (UST) was placed parallel to the cephalocaudal axis of the body in T4 levels on the side of the mid-axillary line, identifying latissimus dorsi and serratus anterior, through the thoracic artery to help to find the serratus anterior and 15 ml 0.25% ropivacaine was administered.
PROCEDUREserratus plane block with saline
The high-frequency linear array ultrasound transducer (UST) was placed parallel to the cephalocaudal axis of the body in T4 levels on the side of the mid-axillary line, identifying latissimus dorsi and serratus anterior, through the thoracic artery to help to find the serratus anterior and 15 ml saline was administered.
Sponsors
Feng Xia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing radical mastectomy with either sentinel lymph node dissection or axillary lymph node dissection or no axillary lymph node dissection * between the ages of 18 and 85 yr * with an American Society of Anesthesiology (ASA) physical status I or II * without any significant cardiopulmonary, renal and hepatic dysfunction
Exclusion criteria
* Patients with any previous cancer other than breast cancer * occurrence of allergy to local anesthetics * occurrence of opioid-tolerant subjects * occurrence of consuming analgesics, sedatives, antidepressants or any history of substance abuse before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numerical Rating Scale (NRS) of chronic pain | 3 months after surgery | Pain intensity of patients was evaluated by Numerical Rating Scale, rating from 0 (no pain) to 10 (extreme pain) in order to evaluate the effect of SPB in preventing chronic pain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the change trend of Numerical Rating Scale (NRS) after surgery | 0-24 hours after operation | Pain intensity of patients was evaluated by Numerical Rating Scale, rating from 0 (no pain) to 10 (extreme pain) in order to evaluate the analgesic effect of SPB |
| Morphine consumption | 0-24 hours after operation | extra need of analgesic |
Countries
China
Outcome results
None listed