Placenta Development Study

Epigenetic Mechanisms Underlying Trophoblast Syncytialization

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03614312

Enrollment

Registered

2018-08-03

Start date

2018-04-17

Completion date

2021-12-22

Last updated

2023-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

This study will help us learn more about how the placenta develops.

Detailed description

The primary purpose of this study is to understand the epigenetic signaling events in placental trophoblast development.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* BMI - 18-25 kg/m2 * at least 18 years of age * singleton pregnancy * less than 36 weeks and plan to deliver in the Little Rock/North Little Rock Area

Exclusion criteria

* Women with pre-existing medical conditions (e.g. diabetes, hypertension, pre-eclampsia, STD, gestational diabetes) * Women who are using recreational drugs, tobacco, or alcohol during their pregnancy. * Women who plan on keeping their placenta following delivery for non-medical reasons.

Design outcomes

Primary

Measure	Time frame	Description
Number of participants that placental syncytial fusion involves epigenetic changes in histone modifications	40 weeks	Number of participants that histone acetyltransferases eszymes, CBP and p300 affect syncytial fusion

Countries

United States

Outcome results