Minimum Anaesthesia Concentration of Lidocaine Required for Sciatic Popliteal Block

Successful Popliteal Block Using Lidocaine; What is the Minimum Effective Anesthesia Concentration (MEAC90)

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03613974

Enrollment

Registered

2018-08-03

Start date

2018-12-15

Completion date

2019-03-31

Last updated

2018-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Procedures

Keywords

foot and ankle, day case surgery

Brief summary

using a biased-coin design up-down sequential method, different concentration of lidocaine will be used for popliteal block After 45 successful block (positive response), the data will be used to calculate the minimum lidocaine concentration that can result in successful popliteal block in 90% of patients

Detailed description

The response of a patient determined the lidocaine concentration given to the next patient (a biased-coin design up-down sequential method). If a patient had a negative response, the lidocaine concentration was increased by 0.1% w/v in the next patient. If a patient had a positive response, the next patient was randomized to receive the same lidocaine concentration (with probability of 0.89), or to receive a concentration 0.1% w/v less (with probability of 0.11).

Interventions

DRUGLidocaine

patients will receive different lidocaine concentrations

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Masking description

the patients and the assessment staff will not be aware with the given lidocaine concentration

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* orthopedic foot or ankle surgery * day case surgery

Exclusion criteria

patients * \<18y, * ASA class greater \>III, * obese (BMI \>30), * patients with low body weight, who required lidocaine dose is of more than 4.5mg.kg-1 * peripheral neuropathy, * motor weakness, * infection at the injection site * any contraindications for medications in the study.

Design outcomes

Primary

Measure	Time frame	Description
successful popliteal block (positive response)	30 min to 3 hour after the block	Sensory block will be assessed using pinprick sensation. Complete sensory block = unable to recognize pinprick sensation. Intra-operative pain will be assessed using Visual Analogue Scale (VAS) 0 = No pain, 10 = Worst imaginable pain. Successful block = complete sensory block + pain free surgery (VAS = 0).

Secondary

Measure	Time frame	Description
motor block	30 min after the block	degree of motor weakness
motor recovery	3 hours till full recovery	complete recover of the motor power
analgesic duration	few hours after block	requesting painkiller

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026