Adverse Effect
Conditions
Keywords
dexmedetomidine, oxygenation index, respiratory index, inflammatory factors
Brief summary
The purpose of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.
Detailed description
Obstructive sleep apnea syndrome is common among people, especially among obese people, Which is characterized by periodic or complete upper airway obstruction and hypoxia during sleep. Intermittent hypoxia contributes to the lung damage by increased oxidative stress, inflammation. Some researchers suggested that dexmedetomidine can inhibit inflammatory reaction and lessen the damage of respiratory function. The aim of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.
Interventions
DRUGdexmedetomidine
receive a loading infusion of dexmedetomidine (1ug/kg)for 20min follow by a maintenance infusion (0.4ug/kg/h) continued until the end of the surgery
OTHERnormal saline
receive matching placebo (equal volum of normal saline)
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing palatopalatyngoplasty * ASA physical status II-III * Aged 18-65 years * BMI 18.5-30kg/m2
Exclusion criteria
* Bradycardia * Atrioventricular block * Allergic to the drugs * Complicating pulmonary disease(including pulmonary infection,COPD, asthma and so on)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Oxygenation Index | Intraoperative and immediately after surgery | Arterial blood samples were sampled before anaesthesia induction and immediately after surgery for the oxygenation index by using blood gas analyzer. |
| The Respiratory Index | Intraoperative and immediately after surgery | Arterial blood samples were sampled before anaesthesia induction and immediately after surgery for the respiratory index by using blood gas analyzer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of tumor necrosis factor-α before anesthesia and immediately after surgery | Intraoperative and immediately after surgery | Blood samples were sampled before anaesthesia induction and immediately after surgery for the serum tumor necrosis factor-α，which were analyzed by using enzyme linked immunosorbent assay (ELISA). |
| Change of interleukin-6 before anesthesia and immediately after surgery | Intraoperative and immediately after surgery | Blood samples were sampled before anaesthesia induction and immediately after surgery for the serum interleukin-6, which were analyzed by using enzyme linked immunosorbent assay (ELISA). |
| Change of interleukin-10 before anesthesia and immediately after surgery | Intraoperative and immediately after surgery | Blood samples were sampled before anaesthesia induction and immediately after surgery for the serum interleukin-10, which were analyzed by using enzyme linked immunosorbent assay (ELISA). |
Countries
China
Contacts
Primary ContactMa Hanxiang
Backup ContactLi Na
Outcome results
None listed