Fibromyalgia
Conditions
Keywords
Fibromyalgia, Pain, Neuroimaging, Sensory sensitivity, Fatigue
Brief summary
This study evaluates whether differences exist between adolescent females with juvenile-onset fibromyalgia and healthy controls in processing of pain and emotion at the neural level as assessed by functional magnetic resonance imaging (fMRI). The study includes a longitudinal component to evaluate changes in neural processing of pain and emotion before and after different treatment strategies.
Detailed description
Juvenile-onset fibromyalgia (JFM) is a chronic, widespread pain condition that primarily affects females. Previous work has shown increased sensitivity to painful and non-painful sensory stimuli in adults with fibromyalgia, as well as brain processing abnormalities associated with these stimuli. These abnormalities in adults are highly predictive of fibromyalgia status (as opposed to healthy status) in adults. Although JFM has some similar symptoms and features to fibromyalgia in adults, the neural mechanisms of JFM may be partially different, given the moment of sharp brain development characterising JFM. fMRI scans will be completed before and after different treatments for JFM (e.g. neuromuscular training + cognitive behavioral therapy, graded aerobic exercise) to investigate the effects of treatment on brain measures related to pain, fatigue and emotion processing.
Interventions
DIAGNOSTIC_TESTFunctional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging scans will be completed to assess neural responses to painful, non-painful sensory, and emotion-eliciting stimuli.
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
13 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of Juvenile Fibromyalgia (by a pediatric rheumatologist or pain physician using 2010 American College of Rheumatology criteria) * Right handed * Functional Disability Index score ≥ 7, indicating at least mild disability * Stable medication regimen for 3 weeks prior to MRI scan
Exclusion criteria
* Non-MRI compatible metal objects in the body (including braces, permanent upper retainers) * Comorbid rheumatic disease (e.g. juvenile arthritis, systemic lupus erythematosus) * Major psychiatric diagnoses (e.g. bipolar disorder, obsessive compulsive disorder, schizophrenia) or documented developmental delay * Taking opioid pain medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional brain activation differences | Baseline | Functional Magnetic Resonance Imaging: differences in pain processing and emotional processing relative to healthy controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional brain activation differences | Baseline and 8 weeks | Functional Magnetic Resonance Imaging: differences in response to painful, non-painful sensory, and emotion-eliciting stimuli before and after treatment |
Countries
United States
Outcome results
None listed