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Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03612245
Acronym
EI-DENTS
Enrollment
403
Registered
2018-08-02
Start date
2008-05-01
Completion date
2012-07-01
Last updated
2018-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infective Endocarditis

Brief summary

Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious disease (20 % of deaths during hospitalization and 40 % after 5 years). The development of an IE results from the meeting between a bacteremia and a pre-existent heart disorder, most of the time valvular, allowing the transplant of the circulating bacteria and their multiplication in the endocardium. Recommendations of prophylactic antibiotic treatment have been established since 1954 for some medical, particularly dental procedures, at the origin of bacteremia. But this policy has recently been questioned because its efficacy has not been demonstrated. The purpose of this study is identify the situations with risk, by comparing the oral health status and the hygiene of patients having an IE with oral streptococci to those in patients having an IE with microorganisms not of oral origin.

Detailed description

It is a case-control observational study. The IE cases are recruited in hospitals participating to the french prospective observational EI2008 cohort. Cases are IE with oral streptococci whereas controls are IE with microorganisms not of oral origin.

Interventions

None listed

Sponsors

Bichat Hospital
CollaboratorOTHER
Central Hospital, Nancy, France
CollaboratorOTHER
CHU de Reims
CollaboratorOTHER
Pitié-Salpêtrière Hospital
CollaboratorOTHER
Rennes University Hospital
CollaboratorOTHER
Centre Hospitalier Universitaire de Besancon
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Major patient * Definite IE caused by oral streptococci (case) or by non-oral pathogens (control)

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Oral health statusDuring the IE eventDental and periodontal evaluation by a dental surgeon or a stomatologist, according to a protocol of standardized examination

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026