Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03612206

Enrollment

113

Registered

2018-08-02

Start date

2017-01-01

Completion date

2018-04-01

Last updated

2018-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Enteral Nutrition, Inflammation

Brief summary

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission * age more than 18 years * Acute Physiology and Chronic Health Evaluation II (APACHE II) score \>8

Exclusion criteria

* not expected to survive 24 hours * pregnancy * any terminal stage disease

Design outcomes

Primary

Measure	Time frame	Description
28-day mortality	14 months	The number of survival and non-survival patients 28 days after inclusion
Intestinal barrier function within one week	14 months	The measurement of serum d-lactate was applied to evaluate the intestinal barrier function

Outcome results