From Structural to Functional Characteristics of the Lumbar Multifidus in Low Back Pain

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03612089

Enrollment

Registered

2018-08-02

Start date

2020-07-27

Completion date

2021-05-31

Last updated

2020-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Low Back Pain, Low Back Pain

Brief summary

To delineate the underlying mechanisms that contribute to chronic low back pain, by extending our knowledge on structural characteristics of the lumbar multifidus muscle using ultrasound muscle imaging, and by examining the association of structural features with functional performance, more precisely proprioceptive control.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

for chronic low back pain group: * Non-specific low back pain, during 3 or more months, without radicular leg pain * Modified Low Back Pain Disability Questionnaire \> 20% * Indication for MRI of the lumbar spine * No contra-indications for MRI * Informed consent to participate Inclusion criteria for healthy control group: * No history of low back pain needing medical treatment or resulting in limited activity level * Any low back pain in the previous 3 months * Informed consent to participate

Exclusion criteria

for all subjects: * Pregnancy * Previous trauma or surgery to spine, abdomen or pelvis * Structural deformity (e.g. scoliosis) * Neurological/neuromuscular/systemic disease * Inability to lie prone for 20 minutes

Design outcomes

Primary

Measure	Time frame	Description
Lumbar multifidus muscle volume measured by 3DfUS	immediately after inclusion in the study	in patients with chronic low back pain
Lumbar multifidus muscle volume measured by MRI	immediately after inclusion in the study	in patients with chronic low back pain
Cross-sectional area of the lumbar multifidus	immediately after inclusion in the study	measured by classic 2D-ultrasound in patients with chronic low back pain and healthy controls
Thickness of the lumbar multifidus	immediately after inclusion in the study	measured by classic 2D-ultrasound in patients with chronic low back pain and healthy controls
Proprioceptive postural control strategies in patients with low back pain with healthy controls	immediately after inclusion in the study	Mean center-of-pressure displacement in response to soleus muscle and/or multifidus muscle vibration (60 Hz, 0.5 mm) during upright standing on two support surfaces.

Countries

Belgium

Contacts

Primary ContactSofie Rummens, MD

sofie.rummens@uzleuven.be+3216342180

Outcome results