Avulsion, Dental Trauma, Periodontal Regeneration, Pulpal Regeneration, Topical Dexamethasone, Topical Tetracycline
Conditions
Brief summary
To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.
Detailed description
Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined. Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.
Interventions
PROCEDURETetracycline
Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation
PROCEDUREDexamethasone
Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation
Sponsors
University of Bern
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Avulsion of a permanent tooth * Written informed consent
Exclusion criteria
* Extended dry period of more than 60 minutes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of teeth with periodontal regeneration | After a mean observation period of 12.9±2.4 years (one visit only) | Periodontal regeneration was assessed with periodontal examination, percussion, Periotest measurements and periapical radiograph. |
| Number of teeth with pulpal regeneration | After a mean observation period of 12.9±2.4 years (one visit only) | Pulpal regeneration was assessed with periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow and periapical radiograph. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of teeth that survived | After a mean observation period of 12.9±2.4 years (one visit only) | Assessed by visual inspection |
| Number of teeth with open versus closed apex at accident | At baseline | Assessed by x-ray |
| Patients satisfaction | After a mean observation period of 12.9±2.4 years (one visit only) | Measured by OHIP-14 score |
Countries
Switzerland
Outcome results
None listed