Atrial Fibrillation, Stroke
Conditions
Brief summary
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years. According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted. The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.
Interventions
BIOLOGICALBlood taken
Collection of clinical data
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Group 1a * Inclusion Criteria : \- AF history *
Exclusion criteria
: * No AF history * patient who didn't signed consent Group 1b * Inclusion Criteria : * AF history * Scheduled electrophysiological exploration or AF ablation *
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of DNA sample | 1 day (the day of the storage) | Quality is based on the measure of the purity of DNA with absorbance assay at 260/280nm on a spectrophotometer. For Plasma sample, purity is based on absence of hemolyzed blood by visual observation. |
| Quality of Plasma sample | 1 day (the day of the storage) | Quality is based on the purity of Plasma sample that is based on absence of hemolyzed blood by visual observation. |
| Quality of preservation of the sample | 7 years (during all the duration of the collection) | The quality of preservation of the sample throughout the conservation duration is based on the number of freezing/thawing of each cryotube that will be notified. As weel as any interruption in the freezing process (power failure, freezer failure). |
Countries
France
Contacts
CONTACTPhilippe CHEVALIER, PU-PH
CONTACTElodie MOREL
Outcome results
None listed