Periodontal Disease, Preterm Labor
Conditions
Brief summary
The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preterm labor. The secondary objective of the study is to analyze the relationship between preterm labor and periodontal infection, using clinical, biochemical and microbiological methods.
Detailed description
Preterm infants are born prior to completion of 37 weeks of gestation. Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preterm labor. It is believed that the results will set light to the etiology of preterm labor and will help to develop strategies to prevent the disease.
Interventions
DIAGNOSTIC_TESTpreterm labor
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
DIAGNOSTIC_TESThealthy
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
Sponsors
Ege University
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 34 Years
Inclusion criteria
* pregnant women with preterm labor * 37\. weeks of pregnant women with no history of preterm labor
Exclusion criteria
* Genitourinary infection * pregnancy or pre-pregnancy hypertension * HIV infection * diabetes mellitus * multiple pregnancy, preterm labor / low birth weight * smoker and alcohol use history * IVF pregnancy * placental, cervical and uterine anomalies * pregnancy with intrauterine growth retardation * pregnancies with congenital or chromosomal fetal anomalies * significant vaginal bleeding * infertility stories * drug addicts * poor socioeconomic level
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prostaglandin E2 | 1 Day | prostaglandin E2 levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml |
| TNF-Alpha | 1 day | TNF-Alpha levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml |
| IL-1beta | 1 day | IL-1beta levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tannerella Forsythia | 1 Day | Presence of Tannerella Forsythia will be checked by rPCR method. Score:1 Present. Score 2: None |
| Porphyromonas gingivalis | 1 Day | Presence of Porphyromonas gingivalis will be checked by rPCR method. Score 1: Present Score 2: None |
Countries
Turkey (Türkiye), United Kingdom
Contacts
Primary ContactGül Yıldız Telatar, Dr.
Backup ContactBeril Gürlek, Dr.
Outcome results
None listed