Multiple Sclerosis
Conditions
Brief summary
We aim to evaluate the role of conventional and advanced MRI sequences in: 1. Establishing the diagnosis of multiple sclerosis and differentiate it from its mimics. 2. Predict the prognosis and evaluate the treatment response in the first year of patients with multiple sclerosis.
Detailed description
All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old). MRI study will be done for each patient. MRI study will be repeated for those already diagnosed as MS after starting the suitable treatment as decided by attending physician after one year to assess the efficacy of treatment and the patient prognosis. MR imaging will be performed on a 1.5-T MR imaging unit (Siemens, Sembra medical system,German). Prospectively completed data forms will be analyzed and compared. Statistical tests appropriate to the nature of the data will be used. All patients will not be subjected to risk of any kind during this study. All patients' data will be confidentially kept. Approval of the ethical committee of Faculty of Medicine, Assiut University. An informed consent will be taken from all patients included in this study. * The research will be conducted only by scientifically qualified and trained personnel. * The procedures included in this study have been already used in hospital and centers in and outside Egypt.
Interventions
DEVICEMRI
magnetic resonance imaging with advanced sequences including tractography,volumetry and inversion recovery
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old).
Exclusion criteria
* o Any general contraindication of MRI in some cases as presence of paramagnetic substance as pacemakers or in patients with claustrophobia. * Patient above 50 years old.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| role of advanced MRI sequences in establishing the diagnosis of multiple sclerosis(MS) | baseline | calculating the sensitivity,specificity and accuracy of diffusion tensor imaging (DTI) and dual inversion recovery(DIR) in differentiating MS from its mimics |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| follow up of MS patients after one year of treatment | one year | assess the degree of brain atrophy after one year mainly in the white matter and cerebral cortex using 3DT1WI |
Contacts
Primary Contactsamaa el-kossi, master
Backup Contactgehan sayed, doctorate
Outcome results
None listed