Prostatectomy
Conditions
Keywords
NGAL, Prostatectomy, Acute kidney injury
Brief summary
The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.
Detailed description
Patients undergoing radical prostatectomy are at increased risk of acute kidney injury (AKI) because of intraoperative bleeding, obstructive uropathy and older age. In particular robot-assisted laparoscopic radical prostatectomy (RALP) which is in increasing demand as an alternative surgical option for retropubic radical prostatectomy (RRP) is associated with postoperative renal dysfunction because pneumoperitoneum during RALP can decrease cardiac output and renal perfusion. NGAL may become important for diagnosis of postoperative AKI after urogenital oncosurgery.
Interventions
PROCEDURENGAL
Sponsors
Antalya Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients who undergo prostatectomy * American Society of Anesthesiology (ASA) I-III
Exclusion criteria
* preexisting renal disease * emergency surgery * heart failure * peripheral vascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma NGAL | 0 hours, 6 hours and 12 hours after surgery | Plasma NGAL was determined at baseline, 6 hours and 12 hours after surgery, ng/ml |
Countries
Turkey (Türkiye)
Outcome results
None listed