Pain
Conditions
Keywords
pain
Brief summary
Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.
Detailed description
The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.
Interventions
BEHAVIORALpain evaluation
collect CSF during spinal anesthesia
Sponsors
National Cheng-Kung University Hospital
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* . Patients undergo spinal anesthesia * . Over 20 years of age * Patients who are competent to understand the study and provide written informed consent.
Exclusion criteria
* Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis) * Refuse participated in this study or pre-existent neurological disease. * Patients with advanced tumor staging (stage 3 or 4).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cytokine measurement in cerebrospinal fluid | through study completion, an average of 1 year | cytokine measurement ( via ELISA) in cerebrospinal fluid |
| cytokine measurement in blood | through study completion, an average of 1 year | cytokine measurement (via ELISA) in blood |
Countries
Taiwan
Outcome results
None listed