Frontotemporal Lobar Degeneration
Conditions
Keywords
Frontotemporal Lobar Degeneration, Behavioral disorders
Brief summary
Fronto-Temporal Lobar Degeneration (FTLD) refers to 3 categories of neurodegenerative diseases generally occurring between 55 and 65 years: Fronto-Temporal Dementia(FTD), Primary Progressive Aphasia (PPA), Semantic Dementia (SD). Clinical expression is substantially variable among individuals, but in most cases, behavioural disorders and personality changes are prominent. FTLD is poorly known by general public including health care professionals. Currently, the French health system does not meet the needs and expectations of patients and their families
Detailed description
Patients with FTLD and their caregivers need to be recognized and supported through specific and tailored made actions provided by expert teams. The main objective of our study is to evaluate the effectiveness of a 6-month personalized multidisciplinary care provided to the dyad FTLD patient and caregiver on patient's behavioural disorders. The secondary objectives are to assess the impact of this program on patient's cognitive deterioration, functional autonomy and behavioral problems, as well as caregiver's depressive symptomatology and sense of competence
Interventions
OTHER3 Home visits made by a psychologist
Patient and caregiver interviews with a psychologist at home
Sponsors
University Hospital, Bordeaux
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patients * Fronto-Temporal Lobar Degeneration diagnoses * Men or women aged 18 and over Caregiver • Spouse, brother, sister, child living at patient's home and can provide the medical team of reliable information on the status of their parent.
Exclusion criteria
: Patient * Patient institutionalized * Pregnant or breast-feeding woman * Psychotic syndrome * Severe and unstable general medical condition * Patient bedridden Caregiver * Persons under legal protection * Severe and unstable general medical condition * Pregnant or breast-feeding woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychiatric Inventory (NPI) | 6 months | Assessment of neuropsychiatric symptomatology |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mini Mental State Examination | 6 months and 12 months | — |
| Frontal Behavioral Inventory | 6 months and 12 months | — |
| Frontal Assessment Battery | 6 months and 12 months | — |
| Neuropsychiatric Inventory (NPI) | 12 months | Assessment of neuropsychiatric symptomatology |
| Sense of Competence Questionnaire (SCQ) | 6 months and 12 months | — |
| Quality of Life Questionnaire (QoL-AD) | 6 months and 12 months | — |
| Hierarchical scale of internality for elderly people (EHIPA) score ( From 0 to 22) | 6 months and 12 months | The score varies from 0 to 22. A high score corresponding to an important internality |
| Geriatric Depression Scale Score ( From 0 to 30) | 6 months and 12 months | Score : 0 - 5 : normal Score : 5 - 9 : light depression Score : 10 - 30 : severe depression |
Countries
France
Outcome results
None listed