Comparison of Cervical Ultrasound and Echoscintigraphy for Preoperative Localization Diagnosis in Primary Hyperparathyroidism

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03605472

Acronym

ECHOPARAT

Enrollment

100

Registered

2018-07-30

Start date

2017-10-05

Completion date

2020-03-05

Last updated

2018-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Hyperparathyroidism

Keywords

primary hyperparathyroidism, cervical ultrasound, echoscintigraphy

Brief summary

The biological diagnosis of the primary hyperparathyroidism is now facilitated by the reliability of the balance of phosphate and calcium and the dosage of parathyroid hormone (PTH). This diagnosis of preoperative localization is important as surgery are now targeted to the responsible lesion. The gold standard for this localization is the cervical ultrasound exploring the usual sites of adenomas and a MIBI scintigraphy (the parathyroid adenoma significantly concentrating this cell marker). However, the diagnosis of preoperative localization remains a subject of discussion as to the most appropriate tests. Indeed, the morphological diagnosis is performed at the ultrasound stage in more than half the cases. It is the new performance of this morphological examination that makes it possible to obtain these results.

Interventions

OTHERcervical ultrasound

cervical ultrasound will be realized by a endocinologist trained in the cervical ultrasound

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with primary hyperparathyroidism with surgery indication * Age \> 18yo

Exclusion criteria

* surgical contraindication * medical treatment by cinacalcet * non sporadic hyperparathyroidism * Age \<18yo * Protected by the law

Design outcomes

Primary

Measure	Time frame	Description
Adenoma parathyroid diagnosed using cervical ultrasound	Day 0	Adenoma parathyroid diagnosed using cervical ultrasound. Cervical ultrasound will be realized by a endocrinologist trained in the cervical ultrasound and not informed of the results of the echoscintigraphy
Adenoma parathyroid diagnosed using echoscintigraphy	Day 0	Adenoma parathyroid diagnosed using echoscintigraphy. Echoscintigraphy will be realized by a nuclear physician not informed of the results of the cervical ultrasound
Adenoma parathyroid diagnosed using anatomopathology	Day 0	Adenoma parathyroid diagnosed by anatomopathologist, after surgery.

Countries

France

Contacts

Primary ContactBrigitte DELEMER

bdelemer@chu-reims.fr0326788101

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026