Elderly, Mortality, Surgery--Complications
Conditions
Keywords
troponin, diastolic function
Brief summary
To document levels of cardiac troponin hsTnT in patients above 75y undergoing high risk surgery and the relationship between elevated levels and outcome in terms of hospital stay and 30 day mortality.
Detailed description
Elevated troponin (Tn) hsTnT levels occur as a result of myocardial damage and are used in the diagnosis of myocardial infarction (MI). However, there are multiple different causes that also result in abnormal Tn levels, such as direct myocardial-cell injury, impaired renal excretion and sepsis. Because of this, elevated Tn level is a common finding in hospitalized patients. Several studies on patients admitted to the intensive care unit (ICU) without MI show that Tn elevation is a mortality risk factor and an independent predictor of hospital mortality. Up till now it is not yet known if the routine measurement of Tn in elderly patients undergoing surgery can significantly improve their outcome and that is the primary aim of this study. In addition, it is not known what the impact could be if a diastolic function assessment could be performed peri-operatively. This study will examine the correlation between elevated Tn levels in elderly patients undergoing major surgery and their short-term outcome (in-hospital). Before and immediately after surgery, diastolic function will be assessed by means of transthoracic echocardiography (TTE).
Interventions
DIAGNOSTIC_TESTlevel of cardiac troponin
blood test
DIAGNOSTIC_TESTdiastolic function assessment
transthoracic echocardiography
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
75 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* All patients ≥75 y undergoing elective and major surgery till we have collected an entire dataset of 100 patients. * Only those patients will be included who are planned for elective and major surgery.
Exclusion criteria
* Patients under the age of 75 * Intraoperative mortality * Eye surgery * Cardiac or thoracic surgery * Patients undergoing surgery which is not withheld as major surgery * For patients undergoing multiple surgeries for the same indication and during the same hospitalization, only the first surgery will be included
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| surgical mortality | 30 days | 30 days mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| diastolic function | 3 days | transthoracic echocardiography |
Countries
Belgium
Outcome results
None listed