Phosphorus and Calcium Disorders
Conditions
Brief summary
BACKGROUND: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (\>3.5 if Ca and P are expressed in mg/dl) from healthy subjects. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP) not related to PHPT, might also impair the Ca/P ratio. OBJECTIVE: To validate the accuracy of Ca/P ratio in the diagnosis of Ca-P metabolism disorders, including also patients with documented HypoP not related to PHPT. METHODS: A single-center, retrospective, case-control study will be carried out. Biochemical measurements will include parathormone (PTH), vitamin D, serum Ca and P, serum albumin and creatinine.
Interventions
Sponsors
Azienda Ospedaliero-Universitaria di Modena
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* patients with diagnosis of primary hyperparathyroidism * HIV-infected patients with reduced phosphorus but normal calcium * subjects with normal Calcium-Phosphorus metabolism
Exclusion criteria
for both cases and controls will be: * age younger than 18 or older than 90 years * severe renal and liver diseases (i.e. glomerular filtration rate (GFR) \<30 ml/min) * hyperparathyroidism secondary to Vitamin D deficiency * active metabolic bone disease (e.g. Paget's disease of the bone, osteomalacia, rickets, etc) * any type of cancer * malnutrition * severe obesity (BMI \> 40 kg/m2) * a history of gastrointestinal malabsorption * sarcoidosis * hypercortisolism * diabetes insipidus * hyperthyroidism * pseudohypoparathyroidism * familial hypocalciuric hypercalcemia (FHH) * treatment with steroids, active forms of vitamin D (calcitriol, ergocalciferol, etc), thiazides, phosphate binders, lithium, cinacalcet, bisphosphonates, and denosumab.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum Calcium to Phosphorus ratio | Assessed only once at the diagnosis (from January 2005 to January 2018) | Calculated formula (serum calcium to serum phosphorus ratio) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum Calcium | Assessed only once at the diagnosis (from January 2005 to January 2018) | From blood sample - Unit of measurement: mg/dl |
| Serum Phosphorus | Assessed only once at the diagnosis (from January 2005 to January 2018) | From blood sample - Unit of measurement: mg/dl |
| Serum Parathormone | Assessed only once at the diagnosis (from January 2005 to January 2018) | From blood sample - Unit of measurement: pg/ml |
Countries
Italy
Outcome results
None listed