Estimating Usual Iodine Intake From Spot Urinary Iodine Concentrations

Estimating the Usual Iodine Intake From Spot Urinary Iodine Concentrations to Obtain the Prevalence of Inadequate or Excess Iodine Intake in School-aged Children and Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03602404

Acronym

ITURN

Enrollment

1592

Registered

2018-07-26

Start date

2018-06-01

Completion date

2020-02-21

Last updated

2022-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iodine Deficiency

Keywords

Iodine

Brief summary

The overall objective of this study is to develop a reliable method to obtain habitual iodine intakes from spot urinary iodine concentration (UIC) and to assess the prevalence of inadequate iodine intake in school-age children and women of reproductive age. We will evaluate different methods to estimate iodine intake from UIC and estimate the prevalence of inadequate and excess iodine intake in UIC studies conducted in populations with low, adequate and high iodine intakes using the the established estimated average requirement (EAR)/Tolerable Upper Intake Level (UL) cut-point method.

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

9 Years to 13 Years

Healthy volunteers

Yes

Inclusion criteria

* lived in study area \>= 12 months * no reported intake of Amiodarone * no history of thyroid dysfunction / goiter (past & present) * no exposure to iodine containing contrast agents within the last 12 months Second arm: Women aged 18 - 49, exclusion / inclusion criteria apply, plus non-pregnant, non-lactating.

Design outcomes

Primary

Measure	Time frame	Description
Estimated iodine intake	17 months	Estimated daily iodine intake of the study population derived from urinary iodine and creatinine concentrations measured in spot urine samples

Secondary

Measure	Time frame	Description
Urinary iodine concentration	17 months	Measured in spot urine samples and 24 h urine collections
Urinary creatinine concentration	17 months	Measured in spot urine samples and 24 h urine collections

Countries

Papua New Guinea, Russia

Outcome results