Seroprevalence Hepatitis E Infection in Healthy Blood Donors

Observational Study on Seroprevalence of Hepatitis E Infection in Healthy Blood Donors in the Canton Ticino

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03601221

Enrollment

1447

Registered

2018-07-26

Start date

2018-05-29

Completion date

2019-12-31

Last updated

2020-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis E

Brief summary

This is a HEV seroprevalence in the health donors in the Canton Ticino study. The pre-donation sampling pouch of each blood donor coming form the Cantone Ticino region will be collected and tested for HEV serology (IgM and IgG).

Detailed description

Pre-donation sampling pouch of fresh and stored frozen plasma collected within the last 5 years will be tested for HEV IgG serology at the National Reference Laboratory of the Blood Transfusion Services SRC in Berne Collected data will be used to determine HEV seroprevalence, actual and in the last 5 years, in the Canton Ticino and to investigate trend and pattern of the HEV infection (seroprevalence by different regional areas, comparison with national HEV data, and correlation with age, sex and place of residence).

Interventions

OTHERSample collection

Collection of one sampling pouch from each blood donor

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Inclusion criteria

* Healthy and voluntary blood donors * Subjects living in the Canton Ticino * Inclusion criteria for blood donation * Signed informed consent of the STCRS SI for blood donation

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
HEV blood incidence	One year	HEV incidence assessed through a single periferal blood sample from each donor

Secondary

Measure	Time frame	Description
change in the blood incidence of HEV	Five years	Determine the change in the incidence of HEV in the Canton Ticino region in the last 5 years analysing the blood sample of the donors.
Geogarphical distribution of the HEV measured in the blood sample	Five years	Determination of the distribution of the HEV infection in different geographical areas of the Canton Ticino analysing donor blood samples
Trend of the HEV infection measured in the blood sample	One year	Evaluation of the trend of the HEV infection in the CantoneTicino compared to other Swiss cantons

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026