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Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction

Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction: a Randomized Controlled Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03601104
Acronym
oclusion
Enrollment
61
Registered
2018-07-26
Start date
2019-03-12
Completion date
2020-12-31
Last updated
2021-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise

Keywords

Eccentric Training, Resistance Training

Brief summary

Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.

Interventions

OTHERHigh intensity eccentric training

High intensity eccentric training group with 80% of isometric peak torque.

OTHERHigh intensity eccentric training with BFR

Eccentric high intensity training group with 80% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

OTHERLow intensity eccentric training with BFR

Low intensity eccentric training group with 40% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

OTHERLow intensity eccentric training

Low intensity eccentric training group with 40% of isometric peak torque

Sponsors

Paulista University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* male sex; * healthy; * aged between 18 and 35 years

Exclusion criteria

* smokers; * alcoholics; * use drugs that influenced cardiac autonomic activity; * cardiovascular, metabolic or endocrine diseases.

Design outcomes

Primary

MeasureTime frameDescription
Change in muscle power testbaseline, fourth week and one week after sixth week.The strength and muscle power tests will be performed on a vertical squat with a guided bar.
Change in muscle strength torque peaks at dinamometer isokineticbaseline, fourth week and one week after sixth weekThe isometric, eccentric and concentric torque peaks will be measured with an isokinetic dynamometer in order to evaluate the adaptations of knee extensor force to eccentric training.
Change in muscular structure with ultrasonographybaseline, fourth week and one week after sixth week.Ultrasonographic imaging of the dominant lower limb will be captured to determine muscle thickness of the vastus lateralis (VL) and rectus femoris (RF) muscles.
Change in Vascular Endothelial Growth Factor (VEGF)baseline, fourth week and one week after sixth week.For the analysis of the concentration of endothelial growth factor (VEGF) will be collected 10 ml of blood sample. The plasma of this sample will be stored at -80 ° C for further analysis.

Secondary

MeasureTime frameDescription
Pain thresholdAssessed at baseline, 4th week, and 6th week.To assess the pain threshold, the pressure algometer will be applied at five specific locations on the quadriceps.
Analog Visual ScaleAssessed at baseline, 4th week, and 6th week.The subjective evaluation of pain will be obtained through the Visual Analogue Scale (EVA), graded from 0 to 10, with zero being the total absence of pain and 10 the maximum level of pain supported by the participant.
Perceived Effort Scale (Borg)Assessed at baseline, 4th week, and 6th week.The degree of subjective exertion reported by the participants in relation to the lower limbs will be analyzed by Borg's scale of perception of effort of 6 to 20 points, 6 being very easy and 20 being exhaustive.
Recovery Perception ScaleAssessed at baseline, 4th week, and 6th week.The perception of recovery of the lower limb submitted to the eccentric exercise protocol will be evaluated by means of a 10-point Likert Scale, where 1 indicates not recovered and 10 fully recovered.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026