Qudratus Lumborum Block for Postoperative Pain After Endoscopic Prostatectomy.

Ultrasound-guided Quadratus Lumborum Block for Postoperative Pain Control After Endoscopic Prostatectomy - Double Blinded, Placebo-controlled, Randomised Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03600129

Enrollment

Registered

2018-07-26

Start date

2018-07-25

Completion date

2019-10-21

Last updated

2019-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Keywords

regional anesthesia, quadratus lumborum block, patient controlled anesthesia, laparoscopic prostatectomy

Brief summary

Laparoscopic prostatectomy (LP) is characterized by substantial tissue trauma, despite its minimally -invasive approach. Although postoperative pain intensity is lower when compared to open procedures, the use of opioids is common. Retrospective review of available LP cases revealed that although analgesic demand varied, nearly all of our LP patients required opioids postoperatively. Bilateral Quadratus Lumborum Block (QLB), being one of relatively new features of regional anesthesia, offers good analgesia of abdominal wall, with the potential for control of visceral pain. This study was established to evaluate its effectiveness in alleviating pain after radical prostatectomy in a double - blind, placebo - controlled manner.

Interventions

PROCEDUREQadratus Lumborum Block

Bilateral, ultrasound - guided Quadratus Lumborum Block

DRUG30 milliliters of 0.375% Ropivacaine

30 milliliters of 0.375% Ropivacaine used for Quadratus Lumborum Block

DRUG30 milliliters of 0.9% NaCl

30 milliliters of 0.9% NaCl used for Quadratus Lumborum Block

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Masking description

Solution used for block (local anesthetic or placebo) is known to anesthetist not involved in patient's care.

Intervention model description

Double blind, placebo-controlled, randomised

Eligibility

Sex/Gender

MALE

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA status less or equal 3 * Scheduled for transperitoneal or extraperitoneal endoscopic prostatectomy * Able to understand information provided and to sign the informed consent for participation in the study

Exclusion criteria

* known allergy to local anesthetics and opioids * infection in the area of block placement * known chronic use of opioids, gabapentinoids and tricyclic antidepressants * mental inability to understand the principles and rules of patient-controlled analgesia pump

Design outcomes

Primary

Measure	Time frame	Description
Opioid consumption following prostatectomy	24 hours	Oxycodone consumption with Patient-Controlled Analgesia pump

Secondary

Measure	Time frame	Description
Pain score	24 hours	Pain scores assessed with Numeric Rating Scale (NRS).In this scale pain intensity is expressed using one of the numbers 0 - 10, 0 being no pain and 10 worst pain imaginable.
Time to first dose of opioid	24 hours	Time in minutes from emergence from anesthesia to the first request for opioid
Opioids - related complications	24 hours	The occurence of symptoms and conditions related to the use of opioids, like nausea, ileus, itching

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026