Huntington Disease
Conditions
Brief summary
The principal means of measuring motor impairment in Huntington disease (HD) is the Unified Huntington's Disease Rating Scale (UHDRS) total motor score, which is subjective, categorical, requires significant training to administer correctly, and only captures impairments in clinic. In this Direct to Phase II SBIR we will develop a wearable sensor system for objective, sensitive, and continuous assessment of Huntington's chorea during activities of daily living. The developed technology could be used clinically to detect changes in motor function in response to medications, or could be used scientifically to expedite and reduce the cost of early stage pharmaceutical clinical trials.
Interventions
OTHERHD Wear
Wearable sensor system for monitoring Huntington's chorea during activities of daily living
Sponsors
University of Rochester
BioSensics
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* CAG expansion ≥ 36
Exclusion criteria
* N/A
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Chorea severity score | 12 months | Remotely monitored chorea severity score based on movement data during activities of daily living |
Countries
United States
Contacts
Primary ContactJoseph Gwin, PhD
Outcome results
None listed