Early Detection and Screening Strategy of Gatric Cancer in Sichuan Province-A Prospective Cohort Study (WCH-GC-SIGES-01)

A Prospective Cohort Study of Early Detection and Screening Strategy for Gatric Cancer in Sichuan Province China (SIGES-01)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03597672

Acronym

SIGES-01

Enrollment

30000

Registered

2018-07-24

Start date

2017-01-01

Completion date

2020-12-31

Last updated

2018-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Atrophic Gastritis, H. Pylori Infection, Neoplasm, Stomach

Keywords

Gastric carcinoma, Early diagnosis, screening stragety, health population cohort

Brief summary

To establish prospective cohort of healthy population and corresponding serum sample bank in Sichuan province to provide platform for exploring early diagnosis and screening strategy of gastric cancer by a prospective cohort study.

Detailed description

H. pylori was one of the most important carcinogenic factor for gastric cancer and play a crucial role in inducing gastritis, atrophy and canceration. Chronic atrophic gastritis (CAG) was a common precancerous disease, people with CAG become high-risk population and need regular follow-up. However, study about occurrence risk prediction for gastric cancer when H. pylori infection concurrence with CAG was still spare. In especial, there was still no population screening program based on serology. The relative clinical epidemiology for providing evidence for China gastric cancer screening program was very rare. This study aim to evaluate gastric cancer occurrence risk and diagnostic value of people combined with H. pylori infection and CAG by Serological methods in Sichuan province China. We also project to design optimized screening program suitable for people in sichuan province China.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Inhabitant in Sichuan province in China (length of residence \> 10 years); 2. Complete physical examination in our hospital, the outcomes was asymptomatic and cancer free healthy individuals; 3. Age between 20 and 70; 4. With normal cognitive and communication ability; 5. Without gastroscopy during recruitment, physical examination item including gastroscopy enrolled in prospective cohort study; 6. Wiling to accept 1-2 times routine physical examination in our hospital; 7. Agree to accept the follow-up of our project group;

Exclusion criteria

1. With history of malignant tumor; 2. Refuse to donate blood specimen; 3. With serious comorbidity and/or finite life (less than 5 years); 4. Request to retreat from this study;

Design outcomes

Primary

Measure	Time frame	Description
The number of new cases of gastric carcinoma	5 years	The new cases of gastric and other epidermal malignant tumor

Secondary

Measure	Time frame	Description
Time of finding nee cases	5 years	The time during SIGES when finding nee gastric cancer and relative disease

Countries

China

Contacts

Primary ContactJian-Kun Hu, M.D. Ph.D.

hujkwch@126.com02885422878

Outcome results