Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients

Primary Prevention With Statin and Incidence of Recurrent Myocardial Infarction and Cardiogenic Shock in Post-Acute Coronary Syndrome Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03596944

Enrollment

145

Registered

2018-07-24

Start date

2017-08-01

Completion date

2018-08-31

Last updated

2018-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome, Cardiogenic Shock, Recurrent Myocardial Infarction

Keywords

acute coronary syndrome, statin, mortality, GRACE score, TIMI score

Brief summary

This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.

Detailed description

Adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under ICD-10 coding of I24.9 were included in this study. The inclusion criteria are patients with primary diagnosis of I24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. Participants were grouped into 2 groups - statin and non-statin based on prior history of statin use prior to ACS. Diagnosis of ACS was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record. Data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. Outcomes of interest were defined as either recurrent myocardial infarction, cardiogenic shock, mortality or combinations of them as diagnosed in the medical records. GRACE and TIMI Scores are calculated to predict in hospital and future mortality rates.

Interventions

DRUGStatin

Prescribed with statins for primary prevention

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Acute Coronary Syndrome * Presence of detail on statin prescription history

Exclusion criteria

* Unavailability of electrocardiographic findings, cardiac marker results, GRACE and TIMI score parameters * Incomplete records of prior medical and treatment history

Design outcomes

Primary

Measure	Time frame	Description
Cardiogenic Shock	Through study completion, an average of 1 year	Clinical Diagnosis of Cardiogenic Shock reported in medical records
Mortality	Through study completion, an average of 1 year	Patient death reported in medical records
Recurrent Myocardial Infarction	Through study completion, an average of 1 year	Clinical Diagnosis of Recurrent Myocardial Infarction reported in medical records

Other

Measure	Time frame	Description
GRACE Score	Through study completion, an average of 1 year	GRACE (Global Registry of Acute Coronary Events) mortality risk score
TIMI Score	Through study completion, an average of 1 year	Thrombolysis In Myocardial Infarction (TIMI) mortality risk score

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026