Meningitis With Cerebral Vasculitis in Children

Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03595761

Enrollment

Registered

2018-07-23

Start date

2017-06-01

Completion date

2017-08-31

Last updated

2018-07-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Meningitis

Keywords

cerebral vasculitis

Brief summary

Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome. The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016). The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging. Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded. The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae

Detailed description

Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children. It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 18 Years

Healthy volunteers

Inclusion criteria

* bacterial meningitis with LCR confirmation

Exclusion criteria

* tuberculous meningitis, immunosuppressor treatment, material like DVP

Design outcomes

Primary

Measure	Time frame	Description
Found a difference demographic data	1 day	Found a difference demographic data between population A and B (age)
Found a difference Clinical manifestation	1 day	Found a difference Clinical manifestation between population A and B
Found a difference Inflammatory parkers	1 day	Found a difference Inflammatory parkers between population A and B
Found a difference Infectious agent	1 day	Found a difference Infectious agent between population A and B

Secondary

Measure	Time frame	Description
Found a difference in the evolution of the diseases between group A and B	1 day	The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.
In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae.	1 day	Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.

Countries

France

Outcome results