Healthy Gut Microbiota
Conditions
Brief summary
This study is designed to examine the shift in gut microbiota and their metabolism after consumption of a dietary supplement (prebiotic) by healthy participants. The investigators will provide participants with a panel of over the counter prebiotics and monitor their gut microbiome response in stool. All prebiotics will be commercially available, over-the-counter food, food additives, or dietary supplements, without any known market-use adverse effects beyond minimal discomfort.
Interventions
DIETARY_SUPPLEMENTPrebiotic A - inulin
Pre-weighed packages will be given twice daily for 5 days.
DIETARY_SUPPLEMENTPrebiotic B - galactooligosaccharides(GOS)
Pre-weighed packages will be given twice daily for 5 days.
DIETARY_SUPPLEMENTPrebiotic C - wheat dextrin
Pre-weighed packages will be given twice daily for 5 days.
Sponsors
Duke University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
17 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Provide Stool Samples at no risk to yourself
Exclusion criteria
* No oral antibiotic treatments within previous 1 month * No known allergy to milk products or lactose intolerance * no known allergy to wheat or gluten intolerance * no history of irritable bowel syndrome * no history of inflammatory bowel disease * no history of type-2 diabetes * no history of chronic kidney disease or reduced kidney function * no current intestinal obstructions * no current untreated colorectal cancer * not currently pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in levels of SCFAs in stool samples | Baseline and 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| change in levels of cytokines in stool samples | Baseline and 6 weeks |
Countries
United States
Outcome results
None listed