Hyper-reduced Liver Grafts, Liver Transplantation, Low-weight Children
Conditions
Keywords
Liver, Transplantation, Hyper-reduction, Graft survival, Overall survival
Brief summary
The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size. Different techniques of hepatic reduction have been described that allow to use larger organs in the pediatric population. However, in these techniques the maximum reduction achieved by segments 2 and 3 is excessive for low-weight children. Since 1997 the liver transplantation group at Hospital Italiano de Buenos Aires has developed and practiced a technique called hepatic hyper-reduction, which consists in reducing the lateral segment of a living donor, adapting the shape and size of the graft to the needs of the recipient. The investigators have performed approximately 50 pediatric liver transplants with live donors in low weight children in whom the hyper-reduction technique has been applied. The aim of the present study is to describe postoperative morbidity and mortality and analyze overall and graft survival.
Interventions
PROCEDURELiver transplantation with hyper-reduced grafts
Live donor liver transplantation using non-anatomical in-situ ultrasound-guided reduction of left lateral segments with preparation of a graft that is larger than a monosegment, but smaller than Segments 2 and 3.
Sponsors
Hospital Italiano de Buenos Aires
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Months to 17 Years
Healthy volunteers
No
Inclusion criteria
* \< or = 17 years old. * Having undergone live donor liver transplantation. * Having received hyper-reduced liver grafts * At the Liver Transplantation Unit of the Hospital Italiano de Buenos Aires * Between June 1997 and April 2018
Exclusion criteria
* \> 17 years old. * Cadaveric liver transplant * Whole liver grafts.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival at 1 year. | Overall survival wil be reported at 1 year after liver transplantation. | Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months. |
| Overall survival at 3 years. | Overall survival wil be reported at 3 years after liver transplantation. | Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months. |
| Overall survival at 10 years. | Overall survival wil be reported at 10 years after liver transplantation. | Overall survival was defined as the time from surgery to death (all causes) or date of last follow-up, measured in months. |
| Graft survival at 1 year. | Graft survival wil be reported at 1 year after liver transplantation. | Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months. |
| Graft survival at 3 years. | Graft survival wil be reported at 3 years after liver transplantation. | Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months. |
| Graft survival at 10 years. | Graft survival wil be reported at 10 years after liver transplantation. | Graft survival was defined as the time from surgery to the date of re-transplantation or re-entry to waiting list, measured in months. |
Countries
Argentina
Outcome results
None listed