Anesthesia, Cesarean Delivery Affecting Newborn, Inflammatory Response
Conditions
Keywords
cesarean section, anesthesia, hs-CRP, NLR
Brief summary
The stress response to surgery is a result of tissue injury with local and systemic inflammation that contributes to the postoperative outcome. Anesthesia is known to effect perioperative stress response Regional anesthesia modifies stress response through afferent blockage whereas general anesthesia affects the stress response via central modulation. High sensitive C-reactive protein and neutrophil to lymphocyte ratio are used for evaluation of inflammation. The aim of this study was to document the value hs-CRP and NLR in perioperative stress response in two different anesthesia methods applied to term pregnant women undergoing elective ceserean section (C/S).
Detailed description
The stress response to surgery is a result of tissue injury with local and systemic inflammation that contributes to the postoperative outcome. Anesthesia is known to effect perioperative stress response. Regional anesthesia modifies stress response through afferent blockage whereas general anesthesia affects the stress response via central modulation. High sensitive C-reactive protein and neutrophil to lymphocyte ratio are used for evaluation of inflammation. The degree of systemic inflammation has been determined by numerous pro- and anti-inflammatory cytokines.The cytokines control the release of C -reactive protein (CRP) which is an acute phase reactant produced by the liver. CRP is a widely used marker of inflammation and tissue damage. High sensitive C -reactive protein (hs-CRP), is a more sensitive assay for detection of inflammation measured by particle-enhanced immunonephelometry . A rapid increase in hs-CRP may indicate inflammation and tissue damage . Another well-known indicator of inflammation is neutrophil-to-lymphocyte ratio (NLR). NLR correlates strongly with elevated plasma levels of circulating proinflammatory cytokineS. The aim of this study was to document the value hs-CRP and NLR in perioperative stress response in two different anesthesia methods applied to term pregnant women undergoing elective ceserean section (C/S).
Interventions
DIAGNOSTIC_TESTHSCRP and NLR
hs-CRP levels and NLR values will be studied from routine blood samples.
Sponsors
Ufuk University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* Healthy pregnant women without chronic diseases at term (36-41 weeks of pregnancy)
Exclusion criteria
* refusal to participate, * chronic diseases (diabetes mellitus, hypertension, heart disease, renal disease, hypo/hyperthyroidism) * any infections, * smoking * contraindications for central neuraxial anesthesia. * Pregnancies complicated with rupture of membranes, placenta previa, eclampsia/preeclampsia, and abruptio placenta * fetal anomalies, * abnormality detected at fetal well-being tests
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the change in HSCRP levels | preoperative, postoperative 2nd and 4th hours, fetal cord blood sample (following delivery) | Measurement of high sensitive C reactive protein levels in different time points in order to evaluate the change in HSCRP levels |
| Evaluation of the change in NLR | preoperative, postoperative 2nd and 4th hours, fetal cord blood sample (following delivery) | Measurement of the Neutrophil to Lymphocyte Ratio in different time points in order to evaluate the change in the Neutrophil to Lymphocyte Ratios |
Countries
Turkey (Türkiye)
Outcome results
None listed