Reproductive Sterility, Sperm Count, Low
Conditions
Keywords
ICSI, progressive sperm count, embryo
Brief summary
The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total progressive sperm number of 2 x 10\^6 after pretreatment as the boundary value, and will divide total progressive sperm number of 2 x 10\^6 after pretreatment into 2 x 10\^6 or higher and \< 2 x 10\^6 groups, and will further divide \< 2 x 10\^6 group into: = 0, (0,10\^6\], (10\^6, 2 x 10\^6) three groups. Propensity score matching will be used to balance the baseline data between four groups. The matching variables are age, female BMI, AFC, AMH and ICSI.
Interventions
OTHERsemen pretreatment
semen pretreatment
Sponsors
Reproductive & Genetic Hospital of CITIC-Xiangya
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* infertility female and sterility male for reproductive treatment
Exclusion criteria
* chromosomal abnormalities * none retrieval oocyte * none oocyte for ICSI * Recurrent abortion * female age≥37 years * Assisted hatching * abnormal oocyte zona pellucida * In Vitro Maturation * AZF microdeletion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| high quality embryo rate for ICSI | two years | rate of embryo grade above 6CI on the third day after fertilization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fertilization rate of ICSI | two years | number of fertilized oocytes/ number of metaphase II oocytes |
| normal fertilization rate of ICSI | two years | number of 2PN fertilized oocytes/ number of metaphase II oocytes |
Countries
China
Outcome results
None listed