Bronchiectasis, Non-tuberculous Mycobacterial
Conditions
Keywords
bronchiectasis, NTM infections, Middle-aged and old women
Brief summary
The purpose of this study is to Understand the prevalence of non-tuberculous mycobacterial(NTM) infections in the middle-aged and old women patients with bronchiectasis in Mainland China, and explore the characteristics of patients with bronchiectasis comorbid NTM.
Detailed description
The development of bronchiectasis is closely related to chronic infection of pathogenic microorganisms .Bronchiectasis and nontuberculous mycobacterial (NTM) infections are inextricably linked Pathophysiologically. But the incidence rate and characteristics of NTM infections among patients with bronchiectasis remains unclear in mainland China. In this study, we will collect data of participants about demographic ,co-morbidities ,spirometry, mMRC score ,exacerbation history, QOL-B questionnaire, aetiology, spirometry , HRCT(or CT) scan ,results of microbiology samples and treatments, collect three consecutive sputum(or induced sputum) samples to smear, bacteria culture, acid-fast stain, mycobacterium cultivation and identification, drug susceptibility testing of nontuberculous mycobacteria.To estimate the prevalance of non-tuberculous mycobacterial(NTM) infections in Middle-aged and old women patients with bronchiectasis in northern China. To analyze clinical manifestations and microbiological characteristics of patients with bronchiectasis comorbid NTM infections By 16SRNA and gene sequencing. In addition, A cross-sectional investigation about lung function and clinical data will be done among patients who have confirmed bronchiectasis with NTM from February 2017 to December 2020.
Interventions
None listed
Sponsors
Bin Cao
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Middle-aged and old women who are \> or = 50 years of age 2. Patients meet the criteria of bronchiectasis
Exclusion criteria
1. Cystic fibrosis 2. After organ transplantation 3. Activity tumor (malignant solid tumor and blood system tumor) 4. Pulmonary interstitial fibrosis with bronchus dilation 5. Allergic bronchopulmonary aspergillosis 6. Diffuse panbronchiolitis 7. Patients refused to sign the informed consent 8. Patients unable to return sputum specimens
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NTM infection rates | 24 months afer enrolled participants | NTM infection rates in Middle-aged and old women patients with bronchiectasis in northern China |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical characteristics of patients with bronchiectasis comorbid NTM infections | 24 months afer enrolled participants | clinical manifestations of patients with bronchiectasis comorbid NTM infections |
| microbiological characteristics of patients with bronchiectasis comorbid NTM infections | 24 months afer enrolled participants | microbiological characteristics of patients with bronchiectasis comorbid NTM |
| Drug resistance of NTM | 24 months afer enrolled participants | drug susceptibility testing outcomes of nontuberculous mycobacteria from sputum samples |
Countries
China
Contacts
Primary ContactHongjun Yin, MD
Backup ContactBen Cao, MD
Outcome results
None listed