The Visual Plasticity During Adversity and Prosperity in Infants With Congenital Cataracts

The Susceptibility of Phenotypic Plasticity During Adversity and Prosperity in Infants With Visual Deprivation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03593824

Enrollment

Registered

2018-07-20

Start date

2012-01-31

Completion date

2013-12-31

Last updated

2018-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract

Keywords

Phenotypic plasticity, Adversity, Prosperity

Brief summary

Phenotypic plasticity is the ability of individuals to change their phenotypic status when exposed to environmental variations. However, whether the plastic changes show differential susceptibility in adversity and prosperity is debated and the specific pattern of plasticity remains elusive. Here the investigators address this question by tracking the phenotypes (functional, structural, physical, and attachment traits) in two groups of infants before and after visual deprivation: one group experienced a short duration of complete deprivation (extreme adversity) and the other group experienced a long durations of partial deprivation (watered-down adversity).

Interventions

PROCEDUREbilateral cataract removal surgery for dense cataract

Participants were born with dense bilateral cataracts (extreme adversity) will undergo surgery for bilateral cataract removal at an early age, mostly around 3 months of age.

PROCEDUREbilateral cataract removal surgery for non-dense nuclear cataract

Participants were born with non-dense and nuclear bilateral cataracts (watered-down adversity) will undergo cataract removal surgery bilaterally in a compromised timing, mostly around one year old.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Diagnosis with dense or non-dense nuclear congenital cataract

Exclusion criteria

* no metabolic diseases, mental retardation or central nervous diseases * had no history of inherited diseases

Design outcomes

Primary

Measure	Time frame
Change from baseline in visual acuity measured by Teller visual acuity cards	1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery

Secondary

Measure	Time frame
Change from baseline in refractive status measured by autorefractor and objective retinoscopy	1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026