Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI

Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03593577

Enrollment

185

Registered

2018-07-20

Start date

2018-06-01

Completion date

2019-06-30

Last updated

2018-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vestibular Schwannoma

Keywords

Schwannoma, saccular dilatation, endolymphatic hydrops, magnetic resonnance imaging, vertigo

Brief summary

Endolymphatic hydrops is well known of the lay public in its primary form that is Ménière disease. Nowadays, the best w ay to approach it in vivo, is to use magnetic resonance imaging (MRI). However, endolymphatic hydrops don't limit itself to its primary form but cover a whole range of pathologies. The hypothesis is that patients with vestibular schwannomas are more likely to develop secondary saccular hydrops. The aim is to compare high-resolution T2-weighted images of the saccule in patients followed up for vestibular schwannomas with healthy volunteers and histological sections from cadavers in order to identify its changes. The secondary purpose of The protocol is to determine if vestibular and audiometric abnormalities could be related to this secondary hydrops more specifically than to the tumor size and localisation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Age\> 18, * Subject having benefited from an MRI with T2 high-resolution 3D sequence (FIESA) in the context of the diagnosis of vestibular schwannoma between 2008 and 2017 at the University Hospitals of Strasbourg, * Subject who has agreed to the use of medical data for the purposes of this research.

Exclusion criteria

* Refusal of the patient to participate in the study * Insufficient imaging data, * Tumors already treated, * Atypical tumors with uncertain diagnosis, intra-labrinthic or intra-labyrinthine schwannomas, concomitant infectious or inflammatory pathology in the middle or inner ear. * Impossibility of giving the subject informed information (difficulty understanding the subject,) * Subject under the protection of justice * Subject under guardianship or curatorship

Design outcomes

Primary

Measure	Time frame
Presence or absence of height and width of the saccule on MRI.	1 hour after the realization of the MRI

Countries

France

Contacts

Primary ContactAïna VENKATASAMY,, MD

aina.venkatasamy@chru-strasbourg.fr33 3 88 12 78 65

Backup ContactAurélie KARCH-GEORGES, MD

aurelie.karch@chru-strasbourg.fr33 3 88 12 78 65

Outcome results